{"release":{"schemaVersion":"maha-epistemic-release/1.0","releaseId":"epirelease_8ffb8cdb8d7841338d8ae69da6fd6eea","releaseKind":"initial","status":"active","recordId":"urn:maha:record:biomolecular-engineering-motif-scaffolding","domainSlug":"biomolecular-engineering","targetSha256":"sha256:ca5e57a43f41f13e0dc0f97c84795152690e1d0bc8fca68488ac2390881a69b9","canonicalPath":"/knowledge/biomolecular-engineering/methods/biomolecular-engineering-motif-scaffolding","canonicalVersion":"1.0.0","supersedesReleaseId":null,"approvals":[{"scope":"boundary-adequacy","reviewId":"epireview_3cbc7d6eaf694c499926e8dd9635128f","reviewSha256":"sha256:0bf7208e9fc1131e93f70c457f97a921d8600c5e6fe34dd39fb6f131f5b457a0","reviewedAt":"2026-08-25T09:34:34.571Z","reviewerKind":"internal-editorial","reviewMethod":"Deterministic exact-hash checks, public source-resolution evidence, source-to-claim audit, unsupported-inference audit, and AI-assisted internal editorial inspection. No external reviewer participated."},{"scope":"domain-fidelity","reviewId":"epireview_7d2a7edd6b0a4585af3fe96ae771fbfb","reviewSha256":"sha256:b4e24970be30e885d50da70ce86bf848b163bdb18b7a7c081c22db94ad8d1f2a","reviewedAt":"2026-08-25T09:34:34.478Z","reviewerKind":"internal-editorial","reviewMethod":"Deterministic exact-hash checks, public source-resolution evidence, source-to-claim audit, unsupported-inference audit, and AI-assisted internal editorial inspection. No external reviewer participated."},{"scope":"rights-and-locator","reviewId":"epireview_f34eb8521c14487a8089a11359e7b42d","reviewSha256":"sha256:cce613d83a69eefeae1f88d29df76d1223209011a6b29b3e96d72156eea35514","reviewedAt":"2026-08-25T09:34:34.794Z","reviewerKind":"internal-editorial","reviewMethod":"Deterministic exact-hash checks, public source-resolution evidence, source-to-claim audit, unsupported-inference audit, and AI-assisted internal editorial inspection. No external reviewer participated."},{"scope":"source-fidelity","reviewId":"epireview_9fec8249dd6745569419d51c6f55e09d","reviewSha256":"sha256:1fff3c8606a85dc9e55f6ef2a0fdd0a1528e309aa12216592c7879c9039de7c3","reviewedAt":"2026-08-25T09:34:34.378Z","reviewerKind":"internal-editorial","reviewMethod":"Deterministic exact-hash checks, public source-resolution evidence, source-to-claim audit, unsupported-inference audit, and AI-assisted internal editorial inspection. No external reviewer participated."}],"assuranceTier":"internally-reviewed-canonical","releaseAuthority":{"authoritySha256":"sha256:38616eafd13c4ad603a3a3a9e445f3862fb29b54385aa571c197a2923e302785","attribution":"withheld-by-consent"},"publicChangeSummary":"Initial canonical publication in the eight-domain internal-review throughput canary.","recordSha256":"sha256:e928b193711c3798d5b9032a0ed450f7eaa0751ce118c102437ec2cd3bfa5f62","gateDecision":{"reasons":[],"recordId":"urn:maha:record:biomolecular-engineering-motif-scaffolding","publicEligible":true,"evaluatedAgainst":"maha-epistemic/1.0"},"releasedAt":"2026-08-25T09:35:10.096Z","releaseSha256":"sha256:f1757c2b7bf8da10e31f69dd72c65aa30fb4e73ea39abe8ac43496f2159d9fde","withdrawal":null},"provenance":{"schemaVersion":"maha-epistemic/1.0","evidencePolicyVersion":"mps/0.1","recordId":"urn:maha:record:biomolecular-engineering-motif-scaffolding","canonicalPath":"/knowledge/biomolecular-engineering/methods/biomolecular-engineering-motif-scaffolding","contentHash":"sha256:e928b193711c3798d5b9032a0ed450f7eaa0751ce118c102437ec2cd3bfa5f62","generatedAt":"2026-08-25T09:35:10.096Z","publicationDecision":{"recordId":"urn:maha:record:biomolecular-engineering-motif-scaffolding","publicEligible":true,"evaluatedAgainst":"maha-epistemic/1.0","reasons":[]},"claims":[{"id":"urn:maha:claim:biomolecular-engineering-motif-scaffolding","scope":"Limited to Abstract; unconditional generation, motif scaffolding, binder design, Methods, and Extended Data. in “De novo design of protein structure and function with RFdiffusion”; this candidate records the concept boundary and does not pool results from uncited systems or studies.","boundary":"Motif scaffolding does not by itself establish system-level performance, safety, manufacturability, scalability, economic advantage, clinical benefit, or deployment readiness.","claimKind":"theoretical-model","sourceIds":["source-biomolecular-engineering-rfdiffusion"],"statement":"The cited source supports treating motif scaffolding as a distinct method within the stated biomolecular engineering scope.","replication":{"asOfDate":"2026-08-24","assessment":"Independent replication and cross-platform transfer have not been compiled for this candidate; the evidence maturity refers only to the bounded source contract.","independentReplicationCount":null},"uncertainty":{"kind":"qualitative","statement":"No cross-source quantitative interval is asserted. Definitions, operating conditions, samples, instruments, and outcome measures must be checked against the exact cited locator during review."},"evidenceMaturity":"single-study"}],"sources":[{"id":"source-biomolecular-engineering-rfdiffusion","url":"https://doi.org/10.1038/s41586-023-06415-8","title":"De novo design of protein structure and function with RFdiffusion","rights":{"note":"The candidate uses original boundary language and a short paraphrase linked to the cited source. No source passage, figure, or table is reproduced.","basis":"citation-with-paraphrase","quotationUsed":false},"authors":["Joseph L. Watson","David Juergens","Nathaniel R. Bennett","et al."],"boundary":"Reported task success does not establish universal folding, binding, safety, or therapeutic function.","publisher":"Nature","establishes":"The study reports diffusion-based generation and experimental tests for specified protein-design tasks.","identifiers":[{"value":"10.1038/s41586-023-06415-8","scheme":"doi"}],"publishedAt":"2023-07-11","exactLocator":"Abstract; unconditional generation, motif scaffolding, binder design, Methods, and Extended Data."}],"reviewEvents":[{"reviewId":"epireview_9fec8249dd6745569419d51c6f55e09d","scope":"source-fidelity","targetSha256":"sha256:ca5e57a43f41f13e0dc0f97c84795152690e1d0bc8fca68488ac2390881a69b9","reviewedAt":"2026-08-25T09:34:34.378Z","verdict":"approve","supersedesReviewId":null},{"reviewId":"epireview_7d2a7edd6b0a4585af3fe96ae771fbfb","scope":"domain-fidelity","targetSha256":"sha256:ca5e57a43f41f13e0dc0f97c84795152690e1d0bc8fca68488ac2390881a69b9","reviewedAt":"2026-08-25T09:34:34.478Z","verdict":"approve","supersedesReviewId":null},{"reviewId":"epireview_3cbc7d6eaf694c499926e8dd9635128f","scope":"boundary-adequacy","targetSha256":"sha256:ca5e57a43f41f13e0dc0f97c84795152690e1d0bc8fca68488ac2390881a69b9","reviewedAt":"2026-08-25T09:34:34.571Z","verdict":"approve","supersedesReviewId":null},{"reviewId":"epireview_f34eb8521c14487a8089a11359e7b42d","scope":"rights-and-locator","targetSha256":"sha256:ca5e57a43f41f13e0dc0f97c84795152690e1d0bc8fca68488ac2390881a69b9","reviewedAt":"2026-08-25T09:34:34.794Z","verdict":"approve","supersedesReviewId":null}]},"privacyBoundary":"Operational actor fingerprints, bearer credentials, private reviewer profiles, affiliations, conflicts, and non-consented authority identity fields are excluded."}